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M9490605.TXT
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1994-09-24
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Document 0605
DOCN M9490605
TI Olfactory pathways in three patients with cryptococcal meningitis and
acquired immune deficiency syndrome.
DT 9411
AU Lima C; Vital JP; Department of Neurology, Hospital Egas Moniz, Lisbon,
Portugal.
SO J Neurol Sci. 1994 May;123(1-2):195-9. Unique Identifier : AIDSLINE
MED/94342933
AB The olfactory mucosa, bulbs and tracts were examined for the presence of
Cryptococcus neoformans in 3 patients with the acquired immune
deficiency syndrome (AIDS) and cryptococcal meningitis. Two of them had
antibodies against HIV-1 and one had positive serology for HIV-2.
Cryptococci were seen in the subarachnoid space around olfactory tracts
and bulbs and in the submucosal olfactory nerve fascicles. In one case,
olfactory nerve fascicles from the lamina propria were also affected.
Olfactory epithelium and respiratory mucosa were not involved. We
suggest that Cryptococcus reached the olfactory nerve fascicles through
the olfactory pathways for cerebrospinal fluid drainage which might
serve as a source of latent cryptococcal infection.
DE Adult AIDS-Related Opportunistic Infections/*PATHOLOGY Case Report
Cryptococcus neoformans/ISOLATION & PURIF Human HIV
Antibodies/ANALYSIS HIV-1 HIV-2 Male Meningitis,
Cryptococcal/ETIOLOGY/*PATHOLOGY Middle Age Olfactory
Bulb/MICROBIOLOGY/*PATHOLOGY Olfactory Mucosa/MICROBIOLOGY/PATHOLOGY
Olfactory Nerve/MICROBIOLOGY/*PATHOLOGY Olfactory
Pathways/MICROBIOLOGY/*PATHOLOGY Subarachnoid Space JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).